Stem cell transplantation in the treatment of myocardial infarction: a visual analysis of international research forefront and development trend

doi:10.3969/j.issn.2095-4344.2014.50.027

Abstract

Abstract:

BACKGROUND: Stem cell transplantation as a new therapy for myocardial infarction has been used more in animal studies, but its clinical application is still faced with many problems, such as choosing the transplantation pathway, inducing the differentiation of transplanted cells, and how to control arrhythmia.
OBJECTIVE: Based on the data from Web of Science database and ClinicalTrials.gov, to analyze the international development trends of stem cell transplantation in the treatment of myocardial infarction, thereby providing a reference basis for relevant researches in this field.
METHODS: (1) The keywords were “stem cell transplantation” and “myocardial infarction”. (2) Time span: 2004-2013. (3) Data source: Web of Science, Citespace III, and ClinicalTrials.gov.
RESULTS AND CONCLUSION: (1) Totally 2 912 literatures addressing stem cell transplantation for myocardial infarction included in Web of Science database from 2004 to 2013 are enrolled and analyzed based on Web of Science database literature analysis report and export information function, using Citespace III information visualization software, to draw co-citation network map. Finally, there are eight high-core classic literatures. (2) There are totally 2 912 articles addressing stem cell transplantation for myocardial infarction included in Web of Science database from 2004 to 2013. Among these 2 912 articles, 1 040 articles are from USA, accounting for 35.714%. The institutions publishing more literatures about stem cell transplantation for myocardial infarction from 2004 to 2013 are Stanford University, Harvard University, Chinese Academy of Medical Sciences, Cincinnati
University, and University of Toronto. Circulation is the journal that has published the most papers (123 papers, accounting for 4.224%) addressing stem cell transplantation for myocardial infarction. The overall number of literatures about stem cell transplantation for myocardial infarction exhibits a gradually increasing trend. The 494 of 2912 papers come from China, which is secondary to the USA. It indicates that there are more scientific achievements in this field in China. (3) There are 22 relevant items registered in ClinicalTrials.gov from 2004 to 2013, all of which belong to interventional studies.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: cardiovascular diseases, heart diseases, stem cells

CLC Number:

R318

Li Xuan, Shi Chun-lai, Wang Xue-yan, Zhang Ming. Stem cell transplantation in the treatment of myocardial infarction: a visual analysis of international research forefront and development trend[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(50): 8189-8195.

Figures/Tables 3

2.1 Web of Science数据库2004至2013年收录干细胞移植应用于心肌梗死研究领域的文献情况分布 2.1.1 文献发表时间分析 2004至2013年Web of Science数据库收录关于干细胞移植应用于心肌梗死研究的文献共2 912条，按发表时间分析文献数量，见图1。 Web of Science数据库2004至2013年收录关于干细胞移植应用于心肌梗死研究文献共2 912篇，2004年收录文献119篇，2005年213篇，2006年229篇，2007年290篇，2008年280篇，2009年323篇，2010年356篇，2011年359篇，2012年374篇，2013年369篇。其中，2005年以后数量涨幅加快，文献数量最多的时间为2012年，374篇。从文献数量的趋势上看，随时间变化文献数量呈逐步上升的趋势。 2.1.2 文献被引频次分析近年来引文已被用于寻找“经典文献”的标准。根据文献计量学，衡量一篇文献质量高低的一个主要标准在于文献的被引用情况，它是同行学者评价文献学术价值的一个重要指标[9]。文献被引用的次数越多，说明该文献的科学影响力越大[10]。Web of Science数据库2004至2013年收录干细胞移植应用于心肌梗死研究文献2 912篇，近10年被引频次较高的文献，见表1。在Web of Science数据库2004至2013年发表干细胞移植应用于心肌梗死研究文献的作者中，Wu, Joseph C.教授发表文献数量最多，41篇。Joseph C. Wu教授为斯坦福大学心血管病研究所主任(http://cvi.stanford. edu/)，其发表的41篇文献中，最高被引次数达到101次。 2.1.3 文献研究热点的可视化分析 CiteSpaceIII是一款由美国德克塞尔大学陈超美博士使用JAVA 语言开发的信息可视化软件，可以直观显示一个学科或知识领域在一定时间的前沿研究和发展趋势[18]。利用Citespace Ⅲ信息可视化软件对Web of Science数据库2004至2013年收录关于干细胞移植应用于心肌梗死研究文献进行可视化分析，选择“Time Slicing”值为1，将2004至2013年的数据分为10个时段处理，选取每一时区被引频次较高的50篇文献，设置阈值为(2，2，20)，(4，3，20)， (4，3，20)，选择节点类型为“Burst terms”，选择Pathfinder network scaling对网络精简，运行得到共引-突现术语可视化分析网络知识图谱，见图2，如图所示，包括节点346个，连线465条。将图2中高被引的经典文献整理后发现，中心度大于0.02的有关文献详见表2。某一领域的研究前沿通过科学家积极引用的文章来体现，它代表了一个研究领域的思想现状。被引用次数多的文献处于核心位置，成为研究领域中的核心成果，但被引频率与文献在研究进程中的贡献没有直接的因果关系。文献在研究进程中的地位和贡献是通过突变值来体现的。科学文献的新趋势和突现的出现是由于：①文献提出一个新发现和科学重大突破。②可能启发科学家从新角度来研究问题[19]。在分析文献共被引网络图谱基础上，对高被引文献进行二次检索，重点分析，寻找干细胞移植应用于心肌梗死研究的前沿领域。8篇高被引论文是本聚类中的核心文献，也是整个共被引网络中的核心文献；每一篇文献都有一个新的发现，是研究的起点，代表了研究的新趋势，引领了研究的一个方向(表2)。 2.1.4 文献类型分析 Web of Science数据库收录2003至2014年干细胞移植应用于心肌梗死相关文献以研究原著为主，其中研究原著2 195篇，占文献总数的75.378%，综述475篇，占16.312%，会议文章141篇，会议摘要103篇，研究原著远远多于其他类型的文献，见表3。会议收录文章也可能同时为Web of Science数据库收录期刊发表的研究原著，在此处将被重复统计。因此所有文献类型分类后的总合将超过数据库收录文章总量。 2.1.5 文献来源国家及机构分布 Web of Science数据库2004至2013年收录关于干细胞移植应用于心肌梗死研究的2 912篇文献中，美国发表文献最多，1 040篇，占文献总数的35.714%，其次为中国，发表文献494篇，占16.964%，德国346篇，日本181篇，意大利136篇，加拿大135篇，英国132篇，韩国121篇，荷兰 114篇，法国102篇。Web of Science数据库2003至2013收录干细胞移植应用于心肌梗死相关文献前10位的国家中，美国发表的文献较多，中国位居第2。Web of Science数据库2003至2013收录干细胞移植应用于心肌梗死的文献数量排在前10位的机构有美国斯坦福大学发表文献76篇，美国哈佛大学发表文献65篇，中国医学科学院发表文献60篇，美国辛辛那提大学发表文献56篇，加拿大多伦多大学发表文献51篇，美国明尼苏达大学，中国协和医科大学各发表文献47篇，中国复旦大学发表文献45篇，美国约翰霍普金斯大学，发表文献41篇，韩国首尔大学发表文献40篇。Web of Science数据库2003至2013年收录干细胞移植应用于心肌梗死的文献数量排在前10位的国家机构中国排在较前位置，说明中国在此领域的科研成果较多。 2.1.6 文献来源期刊分析 Web of Science数据库2004至2013年收录干细胞移植应用于心肌梗死研究文献以心血管和细胞类杂志较多，Circulation (《循环》)发表文献最多，123篇，占全部文献的4.224%，Cell Transplantation (《细胞移植》)发表文献量83篇，占全部文献的2.85%，Stem Cells (《干细胞》)发表文献80篇，占全部文献的2.747%，Circulation Research《循环研究》发表文献78篇，占全部文献的2.679%，International Journal of Cardiology《国际心脏病学杂志》发表文献66篇，占全部文献的2.226%，PLOS ONE，Journal of the American College of Cardiology《美国心脏病学会杂志》各发表文献59篇，占全部文献的2.206%，Journal of Molecular and Cellular Cardiology《分子和细胞心脏病学杂志》发表文献50篇，占全部文献的1.717%，Journal of Cellular and Molecular Medicine《细胞和分子医学杂志》发表文献49篇，占全"

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